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Science. 2008 Aug 8;321(5890):824-6. doi: 10.1126/science.1157312.

Programming DNA tube circumferences.

Author information

  • 1Department of Computer Science, California Institute of Technology, Pasadena, CA 91125, USA. py@caltech.edu

Abstract

Synthesizing molecular tubes with monodisperse, programmable circumferences is an important goal shared by nanotechnology, materials science, and supermolecular chemistry. We program molecular tube circumferences by specifying the complementarity relationships between modular domains in a 42-base single-stranded DNA motif. Single-step annealing results in the self-assembly of long tubes displaying monodisperse circumferences of 4, 5, 6, 7, 8, 10, or 20 DNA helices.

PMID:
18687961
[PubMed - indexed for MEDLINE]
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