Dan Med Bull. 1991 Jun;38(3):284.

Fusidic acid for Behçet's colitis: a novel approach to T-cell specific immunosuppressive therapy.

Langholz E, Brynskov J, Freund LG, Bendtzen K.

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Medicinsk gastroenterologisk afdeling C, Københavns.

Abstract

A 33-year-old patient suffered from recurring Beh,cet's colitis despite treatment with corticosteroids and later cyclosporin. The patient was then successfully shifted from cyclosporin, a T-cell specific immunosuppressant, to fusidic acid treatment (500 mg t.i.d.). During fusidic acid treatment, he went into complete remission, and his prednisolone dose could be reduced from 30 to 5 mg/day. The case report substantiates recent in vitro data indicating that fusidic acid has a similar effect on T-cell function as cyclosporin. It is suggested that the effect of fusidic acid in other chronic immunoinflammatory diseases should be examined.

PMID:: 1868757; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

Reduction of spontaneous autoimmune diabetes in diabetes-prone BB rats with the novel immunosuppressant fusidic acid. Effect on T-cell proliferation and production of interferon-gamma. [Immunology. 1994]
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Effects of sodium fusidate in animal models of insulin-dependent diabetes mellitus and septic shock. [Immunology. 1995]
Effects of sodium fusidate in animal models of insulin-dependent diabetes mellitus and septic shock.
Nicoletti F, Zaccone P, Di Marco R, Magro G, Grasso S, Morrone S, Santoni A, Tempera G, Meroni PL, Bendtzen K. Immunology. 1995 Aug; 85(4):645-50.

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