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Phytother Res. 2009 Jan;23(1):126-8. doi: 10.1002/ptr.2556.

In vitro antiprotozoal activity of some xanthones isolated from the roots of Andrographis paniculata.

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  • 1National Institute of Malaria Research, Field Unit, Sector III, BHEL, Hardwar 249 403, India. vkdua51@gmail.com


Four xanthones isolated from the roots of Andrographis paniculata were tested in vitro for antiprotozoal activity against Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania infantum. Compound TDR13011 (1,2-dihydroxy-6,8-dimethoxy-xanthone) showed good activity against T. b. brucei and L. infantum with a 50% inhibitory concentration (IC50) of 4.6 microg/ml and 8 microg/ml respectively. Xanthones from the roots of Andrographis paniculata exhibited promising anti-protozoal activity and these compounds could be chemically modified to obtain a more potent product.

Copyright 2008 John Wiley & Sons, Ltd.

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