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1: PLoS One. 2008 Aug 6;3(8):e2888.Click here to read Click here to read Links

Generation of breast cancer stem cells through epithelial-mesenchymal transition.

Morel AP, Lièvre M, Thomas C, Hinkal G, Ansieau S, Puisieux A.

Centre Léon Bérard, Lyon, France.

Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells" in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of "cancer stem cells" can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway. The acquisition of these stem and tumorigenic characters is driven by EMT induction.

PMID: 18682804 [PubMed - indexed for MEDLINE]

PMCID: PMC2492808