Send to:

Choose Destination
See comment in PubMed Commons below
Bioinformatics. 2008 Oct 1;24(19):2254-5. doi: 10.1093/bioinformatics/btn407. Epub 2008 Aug 4.

BLogo: a tool for visualization of bias in biological sequences.

Author information

  • 1School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510641, China.


Blogo is a web-based tool that detects and displays statistically significant position-specific sequence bias with reduced background noise. The over-represented and under-represented symbols in a particular position are shown above and below the zero line. When the sequences are in open reading frames, the background frequency of nucleotides could be calculated separately for the three positions of a codon, thus greatly reducing the background noise. The chi(2)-test or Fisher's exact test is used to evaluate the statistical significance of every symbol in every position and only those that are significant are highlighted in the resulting logo. The perl source code of the program is freely available and can be run locally.


[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk