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Cell Metab. 2008 Aug;8(2):99-104. doi: 10.1016/j.cmet.2008.06.012.

Diet and aging.

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  • 1UCL Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK. m.piper@ucl.ac.uk


Interventions that extend life span by moderately reduced nutrient intake are often referred to as dietary or calorie restriction. Its efficacy in many species has led to the conclusion that a single, evolutionarily conserved, molecular mechanism operates in all cases to extend life. Here we discuss examples of diet/genotype interactions that show a more complex mechanistic view is required and that mild dietary modifications can dramatically change the interpretation of model organism aging studies.

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