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Cell Metab. 2008 Aug;8(2):96-8. doi: 10.1016/j.cmet.2008.07.004.

Can exercise mimetics substitute for exercise?

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  • 1Molecular Physiology Group, Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark.


Exercise leads to changes in muscle phenotype with important implications for exercise performance and health. A recent paper in Cell by Narkar et al. (2008) shows that many of the adaptations in muscle phenotype elicited by exercise can be mimicked by genetic manipulation and drug treatment in mice.

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