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Annu Rev Genet. 2008;42:335-59. doi: 10.1146/annurev.genet.42.110807.091620.

Design features of a mitotic spindle: balancing tension and compression at a single microtubule kinetochore interface in budding yeast.

Author information

  • 1Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA. bouck@unc.edu

Abstract

Accurate segregation of duplicated chromosomes ensures that daughter cells get one and only one copy of each chromosome. Errors in chromosome segregation result in aneuploidy and have severe consequences on human health. Incorrect chromosome number and chromosomal instability are hallmarks of tumor cells. Hence, segregation errors are thought to be a major cause of tumorigenesis. A study of the physical mechanical basis of chromosome segregation is essential to understand the processes that can lead to errors. Tremendous progress has been made in recent years in identifying the proteins necessary for chromosome movement and segregation, but the mechanism and structure of critical force generating components and the molecular basis of centromere stiffness remain poorly understood.

PMID:
18680435
[PubMed - indexed for MEDLINE]
PMCID:
PMC2867665
Free PMC Article
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