Localization of the HST/FGFK gene with regard to 11q13 chromosomal breakpoint and fragile site

A Hagemeijer; M Lafage; M G Mattei; J Simonetti; E Smit; O de Lapeyriere; D Birnbaum

doi:10.1002/gcc.2870030307

Localization of the HST/FGFK gene with regard to 11q13 chromosomal breakpoint and fragile site

Genes Chromosomes Cancer. 1991 May;3(3):210-4. doi: 10.1002/gcc.2870030307.

Authors

A Hagemeijer¹, M Lafage, M G Mattei, J Simonetti, E Smit, O de Lapeyriere, D Birnbaum

Affiliation

¹ Erasmus University, Rotterdam, The Netherlands.

PMID: 1868036
DOI: 10.1002/gcc.2870030307

Abstract

The HST/FGFK gene, a member of the fibroblast growth factor gene family and a protooncogene, is localized on chromosomal band 11q13. Genes in this region are frequently involved in hematopoietic and solid tumors. Here we show that the HST gene lies telomeric to the BCL1 gene, the t(11;14)(q13;q32) breakpoint, and the FRA11A rare fragile site.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Banding
Chromosome Fragile Sites
Chromosome Fragility*
Chromosome Mapping
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 14*
Fibroblast Growth Factor 6
Fibroblast Growth Factors / genetics*
Humans
Karyotyping
Leukemia, Prolymphocytic / genetics*
Leukemia, Prolymphocytic / pathology
Male
Metaphase
Middle Aged
Multigene Family*
Proto-Oncogene Proteins / genetics*
Proto-Oncogenes*
Translocation, Genetic*

Substances

FGF6 protein, human
Fibroblast Growth Factor 6
Proto-Oncogene Proteins
Fibroblast Growth Factors