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    Pediatr Nephrol. 1991 May;5(3):277-8.

    Frequency of elevated urinary beta 2-microglobulin levels in relatives of patients with asymptomatic low-molecular-weight proteinuria.

    Kawakami H, Murakami T, Matsuyama S.

    Source

    Department of Pediatrics, Yamaguchi University School of Medicine, Japan.

    Abstract

    We studied urinary beta 2-microglobulin levels in a total of 29 apparently healthy relatives (aged 0.8-70 years) of 8 male patients with asymptomatic low-molecular-weight proteinuria in six families. The frequency of levels above the age- and sex-associated 95% confidence limit was 7 of 29 (24%), 4 of 12 (33%) in first-degree relatives, 2 of 6 (33%) fathers, and 2 of 6 (33%) mothers. These frequencies were significantly above those in the general population (P less than 0.01, by a normal distribution test, a binomial distribution, and Poisson distribution test for the sample proportion). The increased frequency in fathers argues against an X-linked pattern of inheritance for this entity, suggesting that there is heterogeneity in the inheritance.

    PMID:
    1867978
    [PubMed - indexed for MEDLINE]

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