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Nat Genet. 2008 Sep;40(9):1053-5. doi: 10.1038/ng.201.

Identification of loci associated with schizophrenia by genome-wide association and follow-up.

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  • 1Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff, UK. wpcmod@cf.ac.uk

Abstract

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)).

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PMID:
18677311
[PubMed - indexed for MEDLINE]
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