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Neuropharmacology. 2009;56 Suppl 1:169-73. doi: 10.1016/j.neuropharm.2008.07.011. Epub 2008 Jul 16.

Glutamate transmission in addiction.

Author information

  • 1Department of Neurosciences, 173 Ashley Ave, BSB410, Medical University of South Carolina, Charleston, SC 29464, USA. kalivasp@musc.edu

Abstract

Cortico-striatal glutamate transmission has been implicated in both the initiation and expression of addiction related behaviors, such as locomotor sensitization and drug-seeking. While glutamate transmission onto dopamine cells in the ventral tegmental area undergoes transient plasticity important for establishing addiction-related behaviors, glutamatergic plasticity in the nucleus accumbens is critical for the expression of these behaviors. This information points to the value of exploring pharmacotherapeutic manipulation of glutamate plasticity in treating drug addiction.

PMID:
18675832
[PubMed - indexed for MEDLINE]
PMCID:
PMC3280337
Free PMC Article
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