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Vet J. 2009 May;180(2):195-201. doi: 10.1016/j.tvjl.2007.12.026.

Predictive value of natriuretic peptides in dogs with mitral valve disease.

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  • 1Department of Basic Animal and Veterinary Sciences, The Faculty of Life Sciences, University of Copenhagen, 7 Gronnegaardsvej, DK-1870 Frederiksberg C, Denmark. int@life.ku.dk

Abstract

Natriuretic peptides are useful in diagnosing heart failure in dogs. However, their usefulness in detecting early stages of myxomatous mitral valve disease (MMVD) has been debated. This study evaluated N-terminal (NT) fragment pro-atrial natriuretic peptide (NT-proANP) and NT-pro-brain natriuretic peptide (NT-proBNP) in 39 Cavalier King Charles Spaniels (CKCS) with pre-clinical mitral valve regurgitation (MR), sixteen dogs with clinical signs of heart failure (HF) and thirteen healthy control dogs. Twenty seven CKCS and ten control dogs were re-examined 4 years after the initial examination and the status of the dogs 5 years after the initial examination was determined by telephone calls to the owner. All dogs were evaluated by clinical examination and echocardiography. CKCS with severe MR had higher NT-proANP and NT-proBNP compared to controls and CKCS with less severe MR. Dogs with clinical signs of HF had markedly elevated NT-proANP and NT-proBNP. Plasma concentrations of the natriuretic peptides measured at re-examination could predict progression in regurgitant jet size.

PMID:
18675567
[PubMed - indexed for MEDLINE]
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