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Nutr Metab Cardiovasc Dis. 2009 Jan;19(1):15-9. doi: 10.1016/j.numecd.2008.03.007. Epub 2008 Jul 31.

Waist circumference cut-off values to predict the incidence of hypertension: an estimation from a Brazilian population-based cohort.

Author information

  • 1Division of Cardiology, Hospital de ClĂ­nicas de Porto Alegre, UFRGS, Brazil. mgus@terra.com.br

Abstract

BACKGROUND AND AIMS:

Central obesity is a key component in the definition of the metabolic syndrome, but the cut-off values proposed to define abnormal values vary among different guidelines and are mostly based on cross-sectional studies. In this study, we identify the best cut-off values for waist circumference (WC) associated with the incidence of hypertension.

METHODS AND RESULTS:

Participants for this prospectively planned cohort study were 589 individuals who were free of hypertension and selected at random from the community of Porto Alegre, Brazil. Hypertension was defined by a blood pressure measurement >or= 140/90 mmHg or the use of blood pressure lowering drugs. A logistic regression model established the association between WC and the incidence of hypertension. A receiver operating characteristics (ROC) curve analysis was used to select the best WC cut-off point to predict the incidence of hypertension. During a mean follow-up of 5.5+/-0.9 years, 127 subjects developed hypertension. The hazard ratios for the development of hypertension, adjusted for age, baseline systolic blood pressure, alcohol consumption, gender and scholarship were 1.02 (95% CI; 1.00-1.04; P=0.02) for WC. The best cut-off WC values to predict hypertension were 87 cm in men and 80 cm in women, with an area under the curve of 0.56 (95% CI; 0.47-0.64; P=0.17) and 0.70 (95% CI; 0.63-0.77; P<0.001), respectively.

CONCLUSION:

Excess visceral adiposity is a major risk factor for hypertension in individuals living in communities in Brazil, and this risk begins at lower values of WC that those recommended by some guidelines.

PMID:
18674892
[PubMed - indexed for MEDLINE]
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