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1: Mini Rev Med Chem. 2008 Jul;8(8):755-66.Click here to read Links

Inhibitors of c-jun-N-terminal kinase (JNK).

LoGrasso P, Kamenecka T.

Department of Molecular Therapeutics and Drug Discovery, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, FL 33458, USA. lograsso@scripps.edu

Inhibitors of c-jun-N-Terminal Kinase (JNK) have many potential therapeutic indications ranging from neurodegenerative disease, to metabolic disorders, inflammation, cardiovascular disease, and cancer. This overview will highlight biological inhibitors such as JNK-interacting protein (JIP) as well as small molecule inhibitors from various structural classes including, aminopyrimidines and indazoles.

PMID: 18673131 [PubMed - indexed for MEDLINE]