Surg Clin North Am. 2008 Aug;88(4):897-916, viii.

Familial melanoma.

Source

Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, Karolinska University Hospital Solna, S-17176 Stockholm, Sweden. johan.hansson@ki.se

Abstract

Approximately 5% to 10% of cases of cutaneous melanoma occur in families that have a hereditary predisposition for this disease. In 20% to 40% of such melanoma families, germline mutations in the CDKN2A gene have been identified. Apart from a high risk of melanoma, a proportion of kindreds that have familial melanoma also have an increased risk of pancreatic carcinoma. Guidelines for management of familial melanoma and the issue of genetic testing for CDKN2A germline mutations are discussed.

PMID:: 18672145; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

MeSH Terms

Grant Support

R01-CA-083115-06/CA/NCI NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Related citations

Review Familial cutaneous melanoma. [Adv Exp Med Biol. 2010]
Review Familial cutaneous melanoma.
Hansson J. Adv Exp Med Biol. 2010; 685:134-45.
Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome. [Cancer. 2002]
Phenotypic variation in eight extended CDKN2A germline mutation familial atypical multiple mole melanoma-pancreatic carcinoma-prone families: the familial atypical mole melanoma-pancreatic carcinoma syndrome.
Lynch HT, Brand RE, Hogg D, Deters CA, Fusaro RM, Lynch JF, Liu L, Knezetic J, Lassam NJ, Goggins M, et al. Cancer. 2002 Jan 1; 94(1):84-96.
Pancreatic carcinoma surveillance in patients with familial melanoma. [Arch Dermatol. 2003]
Pancreatic carcinoma surveillance in patients with familial melanoma.
Parker JF, Florell SR, Alexander A, DiSario JA, Shami PJ, Leachman SA. Arch Dermatol. 2003 Aug; 139(8):1019-25.
Review Management of familial melanoma. [Lancet Oncol. 2007]
Review Management of familial melanoma.
Bishop JN, Harland M, Randerson-Moor J, Bishop DT. Lancet Oncol. 2007 Jan; 8(1):46-54.
Review Hereditary cutaneous melanoma. [Semin Cancer Biol. 2000]
Review Hereditary cutaneous melanoma.
Platz A, Ringborg U, Hansson J. Semin Cancer Biol. 2000 Aug; 10(4):319-26.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Familial melanoma.
Familial melanoma.
Surg Clin North Am. 2008 Aug ;88(4):897-916, viii.

PubMed
Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for ...
Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer.
Int J Radiat Oncol Biol Phys. 2008 Nov 1 ;72(3):678-86. Epub 2008 Apr 18 .

PubMed
Evaluation of molecular genetic alterations associated with tumor progression in...
Evaluation of molecular genetic alterations associated with tumor progression in a case of gliomatosis cerebri.
J Neurooncol. 2007 Mar ;82(1):23-7. Epub 2006 Sep 6 .

PubMed
The Hippo pathway regulates the bantam microRNA to control cell proliferation an...
The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila.
Cell. 2006 Aug 25 ;126(4):767-74.

PubMed
Assessing the value of the internet in health improvement.
Assessing the value of the internet in health improvement.
Nurs Times. 2004 Aug 31-Sep 6 ;100(35):28-30.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: