Microbes Infect. 2008 Jul;10(9):960-7. Epub 2008 Jul 10.

Role of HIV-1 Vpu protein for virus spread and pathogenesis.

Source

Department of Virology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima, 770-8503, Japan.

Abstract

Vpu is an accessory viral protein almost unique to HIV-1 among primate immunodeficiency viruses, and has two major functions: degradation of the CD4 molecule in endoplasmic reticulum and enhancement of virion release from cells. Recent identification of a novel host restriction factor, tetherin, as a Vpu-antagonist suggests that Vpu contributes to virus spread by facilitating progeny virion production. This review focuses on the two distinct functions of Vpu and summarizes current knowledge on its virological role in the HIV-1 life cycle.

PMID:: 18672082; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

HIV/AIDS - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism. [J Virol. 2009]
Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism.
Douglas JL, Viswanathan K, McCarroll MN, Gustin JK, Früh K, Moses AV. J Virol. 2009 Aug; 83(16):7931-47. Epub 2009 Jun 10.
Review Vpu: a multifunctional protein that enhances the pathogenesis of human immunodeficiency virus type 1. [Curr HIV Res. 2004]
Review Vpu: a multifunctional protein that enhances the pathogenesis of human immunodeficiency virus type 1.
Hout DR, Mulcahy ER, Pacyniak E, Gomez LM, Gomez ML, Stephens EB. Curr HIV Res. 2004 Jul; 2(3):255-70.
Review Modulation of HIV-1-host interaction: role of the Vpu accessory protein. [Retrovirology. 2010]
Review Modulation of HIV-1-host interaction: role of the Vpu accessory protein.
Dubé M, Bego MG, Paquay C, Cohen ÉA. Retrovirology. 2010 Dec 22; 7:114. Epub 2010 Dec 22.
Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue. [Retrovirology. 2010]
Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue.
Schindler M, Rajan D, Banning C, Wimmer P, Koppensteiner H, Iwanski A, Specht A, Sauter D, Dobner T, Kirchhoff F. Retrovirology. 2010 Jan 15; 7:1. Epub 2010 Jan 15.
Mutational analysis of the HIV-1 Vpu protein. [Leukemia. 1994]
Mutational analysis of the HIV-1 Vpu protein.
Friborg J, Yao XJ, Boisvert F, Garzon S, Cohen EA. Leukemia. 1994 Apr; 8 Suppl 1:S156-62.

See reviews... See all...

Cited by 10 PubMed Central articles

The HIV-1 Vpu Protein Induces Apoptosis in Drosophila via Activation of JNK Signaling. [PLoS One. 2012]
The HIV-1 Vpu Protein Induces Apoptosis in Drosophila via Activation of JNK Signaling.
Marchal C, Vinatier G, Sanial M, Plessis A, Pret AM, Limbourg-Bouchon B, Théodore L, Netter S. PLoS One. 2012; 7(3):e34310. Epub 2012 Mar 29.
Site-Directed Mutagenesis of HIV-1 vpu Gene Demonstrates Two Clusters of Replication-Defective Mutants with Distinct Ability to Down-Modulate Cell Surface CD4 and Tetherin. [Front Microbiol. 2010]
Site-Directed Mutagenesis of HIV-1 vpu Gene Demonstrates Two Clusters of Replication-Defective Mutants with Distinct Ability to Down-Modulate Cell Surface CD4 and Tetherin.
Nomaguchi M, Doi N, Fujiwara S, Fujita M, Adachi A. Front Microbiol. 2010; 1:116. Epub 2010 Nov 24.
The unfolded protein response is triggered by a plant viral movement protein. [Plant Physiol. 2011]
The unfolded protein response is triggered by a plant viral movement protein.
Ye C, Dickman MB, Whitham SA, Payton M, Verchot J. Plant Physiol. 2011 Jun; 156(2):741-55. Epub 2011 Apr 6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Role of HIV-1 Vpu protein for virus spread and pathogenesis.
Role of HIV-1 Vpu protein for virus spread and pathogenesis.
Microbes Infect. 2008 Jul ;10(9):960-7. Epub 2008 Jul 10 .

PubMed
Temporal-spatial expression and novel biochemical properties of the memory-relat...
Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA.
Neuroscience. 2008 Sep 9 ;155(4):1165-73. Epub 2008 Jul 3 .

PubMed
Inflammation, ageing and cancer.
Inflammation, ageing and cancer.
Mech Ageing Dev. 2009 Jan-Feb ;130(1-2):40-5. Epub 2008 Jul 10 .

PubMed
Occurrence of a Tyr393----Asn (Y393N) mutation in the E1 alpha gene of the branc...
Occurrence of a Tyr393----Asn (Y393N) mutation in the E1 alpha gene of the branched-chain alpha-keto acid dehydrogenase complex in maple syrup urine disease patients from a Mennonite population.
Am J Hum Genet. 1991 Aug ;49(2):429-34.

PubMed
IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-depen...
IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription.
FEBS Lett. 2008 Aug 20 ;582(19):2833-7. Epub 2008 Jul 29 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: