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    FEBS Lett. 2008 Aug 20;582(19):2833-7. Epub 2008 Jul 29.

    IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription.

    Kimura M.

    Source

    Gene Engineering Division, RIKEN, 3-1-1 Koyadai, Tsukuba, Ibaraki, Japan. makimura@riken.jp

    Abstract

    Jun-dimerization protein 2 (JDP2) is a member of the activating protein-1 (AP-1) family of transcription factors. JDP2 dimerizes with other AP-1 proteins such as activating transcription factor-2 (ATF2) and Jun to repress transcription from promoters that contain a cyclic AMP-responsive element (CRE). Interferon regulatory factor-2-binding protein-1 (IRF2-BP1), which is reported to be a transcriptional corepressor of IRF2, was isolated as a JDP2-binding protein using an epitope-tagging method. As anticipated from the presence of a RING-finger domain, IRF2-BP1 enhanced the polyubiquitination of JDP2. Moreover, IRF2-BP1 repressed ATF2-mediated transcriptional activation from a CRE-containing promoter.

    PMID:
    18671972
    [PubMed - indexed for MEDLINE]

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