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J Med Primatol. 2009 Feb;38(1):51-8. doi: 10.1111/j.1600-0684.2008.00307.x. Epub 2008 Jul 30.

Spontaneous heart disease in the adult chimpanzee (Pan troglodytes).

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  • 1College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

Abstract

BACKGROUND:

A high incidence of heart disease, especially idiopathic cardiomyopathy (IC), is seen in chimpanzees (Pan troglodytes).

METHODS:

We reviewed clinical records and necropsy reports of 87 adult chimpanzees for possible causes of heart disease/IC. We examined age, sex, cause of death, weight, diet, environment, infectious diseases, experimental uses and clinical pathology.

RESULTS:

The overall prevalence of heart disease in chimpanzees was 67.81%; the prevalence of IC was 51.72%. The prevalence of IC was significantly higher in males (60.32%) than that in females (29.17%, P = 0.009). The prevalence of other heart disease was higher in females (25%) than that in males (12.70%, P = 0.165). Heart failure occurred in 47.13% of chimpanzees. Heart disease was the primary cause of death in 34.49% of chimpanzees; 29.88% died of unknown causes.

CONCLUSIONS:

We found no evidence that diet, environment, viral agents, experimental use or disease exposure contributed to the deaths resulting from IC in chimpanzees.

Comment in

PMID:
18671767
[PubMed - indexed for MEDLINE]
PMCID:
PMC2933140
Free PMC Article

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