Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Acta Paediatr. 2008 Oct;97(10):1465-9. doi: 10.1111/j.1651-2227.2008.00937.x. Epub 2008 Jul 28.

Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years.

Author information

  • 1Center for Research in Environmental Epidemiology, Institut Municipal Investigació Mèdica, Barcelona, Spain. nribas@imim.es

Abstract

AIM:

To determine whether prenatal exposure to hexachlorobenzene (HCB) has potential adverse effects on child's weight and body mass index (BMI) in a general population with no local pollution sources.

METHODS:

Starting from mid 1997, all mothers presenting for antenatal exposure in Menorca were recruited. Subsequently, 482 children were enrolled. HCB was measured in cord blood. Weight and height were measured at birth and at age 6.5 years.

RESULTS:

Children with HCB levels higher than 1.03 ng/mL in cord blood were 1.14 kg (0.38) heavier and had a higher BMI (beta= 0.80 (0.34)) than children with HCB levels lower than 0.46 ng/mL. No statistically significant associations were found in height. Children in the higher exposure group of HCB had an increased risk of 2.5 and 3.0 of being overweight and obese. Children from normal weight mothers also presented an increased risk of having higher BMI with increasing concentrations of HCB in cord serum.

CONCLUSION:

Prenatal exposure to HCB is associated with an increase in BMI and weight at age 6.5 years. Further studies with larger samples and longer follow-up are needed to confirm these results.

PMID:
18665907
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk