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J Pediatr Gastroenterol Nutr. 2008 Aug;47(2):179-86. doi: 10.1097/MPG.0b013e318162c428.

Taurolidine and catheter-related bloodstream infection: a systematic review of the literature.

Author information

  • 1Department of Pediatrics, Calderdale Royal Hospital, Salterhebble, Halifax, UK. jo.bradshaw@cht.nhs.uk

Abstract

BACKGROUND:

Catheter-related bloodstream infection remains the most common serious complication associated with long-term parenteral nutrition. Taurolock (Bio-Implant HealthCare, Winsen, Germany), which contains taurolidine, is being marketed as a central venous catheter lock solution for decreasing the risk of catheter sepsis.

AIM:

To review available literature and examine the evidence for efficacy of taurolidine in prevention of central venous catheter-related infection.

MATERIALS AND METHODS:

Search of MEDLINE, Embase, and the Internet for all studies involving use of taurolidine to prevent central venous catheter infection.

RESULTS:

Six in vitro and 11 in vivo studies were assessed. Although in vivo studies suggest a possible useful role for taurolidine, the evidence base from clinical studies is poor, with much of it observational or of poor methodology.

CONCLUSIONS:

The evidence is insufficient to warrant routine use of taurolidine. However, results of in vitro studies are encouraging and further adequately powered and well-designed randomized trials are required.

PMID:
18664870
[PubMed - indexed for MEDLINE]
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