Send to:

Choose Destination
See comment in PubMed Commons below
Int J Pharm. 2008 Dec 8;364(2):265-71. doi: 10.1016/j.ijpharm.2008.06.030. Epub 2008 Jul 9.

Immunomodulatory biomaterials.

Author information

  • 1Department of Chemical and Biological Engineering, Iowa State University, 2035 Sweeney Hall, Ames, IA 50011-2230, USA.


Vaccination is one of the most successful medical interventions for the prevention of disease in the twentieth century. However, with the development of new and less reactogenic vaccine antigens, which take advantage of molecular recombinant technologies, comes the need for more effective adjuvants that will facilitate the induction of adaptive immune responses. In this context, immunomodulatory biomaterials, particularly the ones based on biodegradable polymers, show great promise. This article discusses the various classes of immunomodulatory biomaterials and advocates a cross-disciplinary approach that brings together molecular concepts from various fields to rationally design vaccine adjuvants with immunomodulatory properties.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk