Ophthalmology. 1991 Jun;98(6):847-53.

Use of corticosteroids in combination with antimicrobial drugs in the treatment of infectious corneal disease.

Source

Department of Ophthalmology, University of Florida College of Medicine, Gainesville 32610.

Abstract

The use of corticosteroids in the management of infectious eye disease is controversial. In this study, the authors attempt to analyze the goals and risks of the use of corticosteroids in the treatment of various forms of infectious keratitis with reference to generally recognized principles for the treatment of infectious diseases. Existing clinical and research data are reviewed in this context to make appropriate recommendations for the use of corticosteroids in the treatment of bacterial, fungal, and acanthamoeba keratitis. The authors conclude that corticosteroids are definitely contraindicated in the treatment of fungal keratitis, and relatively contraindicated in the treatment of Acanthamoeba keratitis. Topical corticosteroid therapy may have a role in the treatment of bacterial keratitis if appropriate guidelines are followed.

Comment in

Ophthalmology. 1991 Jun;98(6):845-6.

PMID:: 1866135; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Supplemental Content

Save items

Related citations in PubMed

Microbial keratitis: what's the preferred initial therapy? View 1: corneal scraping and combination antibiotic therapy is indicated. [Br J Ophthalmol. 2003]
Microbial keratitis: what's the preferred initial therapy? View 1: corneal scraping and combination antibiotic therapy is indicated.
Mills R. Br J Ophthalmol. 2003 Sep; 87(9):1167-9.
Review Topical corticosteroids as adjunctive therapy for bacterial keratitis. [Cochrane Database Syst Rev. 2007]
Review Topical corticosteroids as adjunctive therapy for bacterial keratitis.
Suwan-Apichon O, Reyes JM, Herretes S, Vedula SS, Chuck RS. Cochrane Database Syst Rev. 2007 Oct 17; (4):CD005430. Epub 2007 Oct 17.
Review Fusarium keratitis following the use of topical antibiotic-corticosteroid therapy in traumatised eyes. [Ann Acad Med Singapore. 1996]
Review Fusarium keratitis following the use of topical antibiotic-corticosteroid therapy in traumatised eyes.
Wong TY, Au Eong KG, Chan WK, Tseng PS. Ann Acad Med Singapore. 1996 Nov; 25(6):862-5.
Study of the first contact management profile of cases of infectious keratitis: a hospital-based study. [Cornea. 2000]
Study of the first contact management profile of cases of infectious keratitis: a hospital-based study.
Vajpayee RB, Dada T, Saxena R, Vajpayee M, Taylor HR, Venkatesh P, Sharma N. Cornea. 2000 Jan; 19(1):52-6.
Review Infectious keratitis. [Curr Opin Infect Dis. 2007]
Review Infectious keratitis.
Thomas PA, Geraldine P. Curr Opin Infect Dis. 2007 Apr; 20(2):129-41.

See reviews... See all...

Cited by 14 PubMed Central articles

Bacterial keratitis: perspective on epidemiology, clinico-pathogenesis, diagnosis and treatment. [Sultan Qaboos Univ Med J. 2009]
Bacterial keratitis: perspective on epidemiology, clinico-pathogenesis, diagnosis and treatment.
Al-Mujaini A, Al-Kharusi N, Thakral A, Wali UK. Sultan Qaboos Univ Med J. 2009 Aug; 9(2):184-95. Epub 2009 Jun 30.
Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis. [Clin Ophthalmol. 2010]
Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis.
Al-Badriyeh D, Neoh CF, Stewart K, Kong DC. Clin Ophthalmol. 2010 May 6; 4:391-405. Epub 2010 May 6.
Genotypic identification of Fusarium species from ocular sources: comparison to morphologic classification and antifungal sensitivity testing (an AOS thesis). [Trans Am Ophthalmol Soc. 2008]
Genotypic identification of Fusarium species from ocular sources: comparison to morphologic classification and antifungal sensitivity testing (an AOS thesis).
Alfonso EC. Trans Am Ophthalmol Soc. 2008; 106:227-39.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Use of corticosteroids in combination with antimicrobial drugs in the treatment ...
Use of corticosteroids in combination with antimicrobial drugs in the treatment of infectious corneal disease.
Ophthalmology. 1991 Jun ;98(6):847-53.

PubMed
Extracellular matrix: a matter of life and death.
Extracellular matrix: a matter of life and death.
Connect Tissue Res. 2008 ;49(3):203-6.

PubMed
A computational screen for C/D box snoRNAs in the human genomic region associate...
A computational screen for C/D box snoRNAs in the human genomic region associated with Prader-Willi and Angelman syndromes.
J Biomed Sci. 2008 Nov ;15(6):697-705. Epub 2008 Jul 27 .

PubMed
The 70-gene prognosis-signature predicts disease outcome in breast cancer patien...
The 70-gene prognosis-signature predicts disease outcome in breast cancer patients with 1-3 positive lymph nodes in an independent validation study.
Breast Cancer Res Treat. 2009 Jul ;116(2):295-302. Epub 2008 Jul 27 .

PubMed
Comfort of general internists and general pediatricians in providing care for yo...
Comfort of general internists and general pediatricians in providing care for young adults with chronic illnesses of childhood.
J Gen Intern Med. 2008 Oct ;23(10):1621-7. Epub 2008 Jul 26 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: