Nat Med. 2008 Aug;14(8):819-21. doi: 10.1038/nm.1850. Epub 2008 Jul 27.

Effective induction of high-titer antibodies by viral vector vaccines.

Draper SJ, Moore AC, Goodman AL, Long CA, Holder AA, Gilbert SC, Hill F, Hill AV.

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The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK. simon.draper@ndm.ox.ac.uk

Abstract

Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.

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Effective induction of high-titer antibodies by viral vector vaccines.
Effective induction of high-titer antibodies by viral vector vaccines.
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