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J Biol Chem. 2008 Nov 14;283(46):31269-73. doi: 10.1074/jbc.R800029200. Epub 2008 Jul 25.

Mechanisms of YidC-mediated insertion and assembly of multimeric membrane protein complexes.

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  • 1Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, the Zernike Institute of Advanced Materials, The Netherlands.


The YidC protein fulfills a dual and essential role in the assembly of inner membrane proteins in Escherichia coli. Besides interacting with transmembrane segments of newly synthesized membrane proteins that insert into the membrane via the SecYEG complex, YidC also functions as an independent membrane protein insertase and assists in membrane protein folding. Here, we discuss the mechanisms of YidC substrate recognition and membrane insertion with emphasis on its role in the assembly of multimeric membrane protein complexes such as the F1F0-ATP synthase.

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