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Int J Cardiol. 2008 Nov 12;130(2):147-58. doi: 10.1016/j.ijcard.2008.04.059. Epub 2008 Jul 25.

Macrophage roles following myocardial infarction.

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  • 1Medical Student Research Stipend Program, UTHSCSA, TX 78229-3900, USA.


Following myocardial infarction (MI), circulating blood monocytes respond to chemotactic factors, migrate into the infarcted myocardium, and differentiate into macrophages. At the injury site, macrophages remove necrotic cardiac myocytes and apoptotic neutrophils; secrete cytokines, chemokines, and growth factors; and modulate phases of the angiogenic response. As such, the macrophage is a primary responder cell type that is involved in the regulation of post-MI wound healing at multiple levels. This review summarizes what is currently known about macrophage functions post-MI and borrows literature from other injury and inflammatory models to speculate on additional roles. Basic science and clinical avenues that remain to be explored are also discussed.

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