J Cell Biochem. 2008 Oct 1;105(2):338-43.

Vitamin D and multiple sclerosis.

Source

Department of Biochemistry and Molecular Biology, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, USA.

Abstract

Vitamin D is a principal regulator of calcium homeostasis. However, recent evidence has indicated that vitamin D can have numerous other physiological functions including inhibition of proliferation of a number of malignant cells including breast and prostate cancer cells and protection against certain immune mediated disorders including multiple sclerosis (MS). The geographic incidence of MS indicates an increase in MS with a decrease in sunlight exposure. Since vitamin D is produced in the skin by solar or UV irradiation and high serum levels of 25-hydroxyvitamin D (25(OH)D) have been reported to correlate with a reduced risk of MS, a protective role of vitamin D is suggested. Mechanisms whereby the active form of vitamin D, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) may act to mediate this protective effect are reviewed. Due to its immunosuppressive actions, it has been suggested that 1,25(OH)(2)D(3) may prevent the induction of MS.

PMID:: 18655192; [PubMed - indexed for MEDLINE]
PMCID: PMC2859312

Free PMC Article

Images from this publication.See all images (1) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Related citations

Review The role of vitamin D in multiple sclerosis. [J Photochem Photobiol B. 2010]
Review The role of vitamin D in multiple sclerosis.
Kampman MT, Steffensen LH. J Photochem Photobiol B. 2010 Nov 3; 101(2):137-41. Epub 2010 Apr 21.
Final Report on Carcinogens Background Document for Formaldehyde. [Rep Carcinog Backgr Doc. 2010]
Final Report on Carcinogens Background Document for Formaldehyde.
National Toxicology Program. Rep Carcinog Backgr Doc. 2010 Jan; (10-5981):i-512.
Review Vitamin D and multiple sclerosis: an update. [Nutr Rev. 2008]
Review Vitamin D and multiple sclerosis: an update.
Cantorna MT. Nutr Rev. 2008 Oct; 66(10 Suppl 2):S135-8.
Review Multiple sclerosis and vitamin D: an update. [Eur J Clin Nutr. 2004]
Review Multiple sclerosis and vitamin D: an update.
VanAmerongen BM, Dijkstra CD, Lips P, Polman CH. Eur J Clin Nutr. 2004 Aug; 58(8):1095-109.
Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role? [Lung Cancer. 2007]
Seasonal and geographical variations in lung cancer prognosis in Norway. Does Vitamin D from the sun play a role?
Porojnicu AC, Robsahm TE, Dahlback A, Berg JP, Christiani D, Bruland OS, Moan J. Lung Cancer. 2007 Mar; 55(3):263-70. Epub 2007 Jan 17.

See reviews... See all...

Cited by 7 PubMed Central articles

Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis. [Neurol Res Int. 2011]
Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis.
Wootla B, Denic A, Keegan BM, Winters JL, Astapenko D, Warrington AE, Bieber AJ, Rodriguez M. Neurol Res Int. 2011; 2011:780712. Epub 2011 Sep 22.
Review Vitamin D in health and disease: current perspectives. [Nutr J. 2010]
Review Vitamin D in health and disease: current perspectives.
Zhang R, Naughton DP. Nutr J. 2010 Dec 8; 9:65. Epub 2010 Dec 8.
Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis. [PLoS One. 2010]
Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis.
Stoop MP, Singh V, Dekker LJ, Titulaer MK, Stingl C, Burgers PC, Sillevis Smitt PA, Hintzen RQ, Luider TM. PLoS One. 2010 Aug 27; 5(8):e12442. Epub 2010 Aug 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Vitamin D and multiple sclerosis.
Vitamin D and multiple sclerosis.
J Cell Biochem. 2008 Oct 1 ;105(2):338-43.

PubMed
Working memory capacity and fluid intelligence are strongly related constructs: ...
Working memory capacity and fluid intelligence are strongly related constructs: comment on Ackerman, Beier, and Boyle (2005).
Psychol Bull. 2005 Jan ;131(1):66-71; author reply 72-5.

PubMed
Working memory and intelligence: the same or different constructs?
Working memory and intelligence: the same or different constructs?
Psychol Bull. 2005 Jan ;131(1):30-60.

PubMed
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek...
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.
J Biol Chem. 2003 Sep 12 ;278(37):34897-909. Epub 2003 Jul 2 .

PubMed
Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in ...
Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis.
Neuropharmacology. 2003 Oct ;45(5):672-83.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: