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J Nat Prod. 2008 Aug;71(8):1323-6. doi: 10.1021/np8002595. Epub 2008 Jul 23.

Epoxydons and a pyrone from the marine-derived fungus Nigrospora sp. PSU-F5.

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  • 1Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand.


Nigrospoxydons A-C (1- 3) and nigrosporapyrone (4), four new metabolites, were isolated from the marine-derived fungus Nigrospora sp. PSU-F5 together with nine known compounds. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D NMR spectroscopic techniques. The antibacterial activity against the standard Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus was evaluated.

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