Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cell Res. 2008 Aug;18(8):817-22. doi: 10.1038/cr.2008.85.

NKT cells in HIV-1 infection.

Author information

  • 1MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Headington, Oxford OX3 9DS, United Kingdom. demin.li@imm.ox.ac.uk

Abstract

Natural killer T (NKT) cells are a unique T cell population that have important immunoregulatory functions and have been shown to be involved in host immunity against a range of microorganisms. It also emerges that they might play a role in HIV-1 infection, and therefore be selectively depleted during the early stages of infection. Recent studies are reviewed regarding the dynamics of NKT depletion during HIV-1 infection and their recovery under highly active antiretroviral treatment (HAART). Possible mechanisms for these changes are proposed based on the recent developments in HIV pathogenesis. Further discussions are focused on HIV's disruption of NKT activation by downregulating CD1d expression on antigen presentation cells (APC). HIV-1 protein Nef is found to play the major role by interrupting the intracellular trafficking of nascent and recycling CD1d molecules.

PMID:
18645582
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk