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Trends Ecol Evol. 2008 Sep;23(9):502-10. doi: 10.1016/j.tree.2008.06.001. Epub 2008 Jul 19.

Pleiotropy in the melanocortin system, coloration and behavioural syndromes.

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  • 1Department of Ecology and Evolution, University of Lausanne, Biophore, CH-1015 Lausanne, Switzerland.

Abstract

In vertebrates, melanin-based coloration is often associated with variation in physiological and behavioural traits. We propose that this association stems from pleiotropic effects of the genes regulating the synthesis of brown to black eumelanin. The most important regulators are the melanocortin 1 receptor and its ligands, the melanocortin agonists and the agouti-signalling protein antagonist. On the basis of the physiological and behavioural functions of the melanocortins, we predict five categories of traits correlated with melanin-based coloration. A review of the literature indeed reveals that, as predicted, darker wild vertebrates are more aggressive, sexually active and resistant to stress than lighter individuals. Pleiotropic effects of the melanocortins might thus account for the widespread covariance between melanin-based coloration and other phenotypic traits in vertebrates.

PMID:
18644658
[PubMed - indexed for MEDLINE]
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