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Clin Infect Dis. 2008 Sep 1;47(5):e52-6. doi: 10.1086/590968.

Mortality secondary to fulminant hepatic failure in patients with prior resolution of hepatitis B virus infection in Japan.

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  • 1Department of Internal Medicine, Hepatology, and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan. tumemura@shinshu-u.ac.jp


Hepatitis B virus (HBV) reactivation in patients with resolved HBV infection was found in 23 (4%) of 552 newly hepatitis B surface antigen-positive patients in Japan. Because one-fourth of cases develop into fulminant hepatic failure and mortality is 100%, management of HBV reactivation in patients with resolved HBV infection should be discussed.

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