Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Drug Discov Today. 2008 Oct;13(19-20):875-81. doi: 10.1016/j.drudis.2008.06.012. Epub 2008 Aug 3.

Progress in the evaluation of CDK inhibitors as anti-tumor agents.

Author information

  • Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA. mcinnes@sccp.sc.edu

Abstract

The increase in understanding of the events of cell growth and division has enabled the development of pharmacological agents inhibiting key regulatory proteins, with the cyclin dependent kinases (CDKs) representing a major area of interest. Owing to multiple CDK variants having cell cycle and transcriptional regulatory roles and difficulties in generating selective inhibitors, the prospects for drug discovery and development are complex. Numerous CDK inhibitors with differing mechanistic profiles are currently being preclinically and clinically evaluated but have not as of yet resulted in a drug approval. The major issues of CDK inhibition related to current understanding from genetic studies and also from observed anti-tumor efficacy of representative compounds are discussed in this review.

PMID:
18639646
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk