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J Agric Food Chem. 2008 Aug 13;56(15):6378-81. doi: 10.1021/jf800870b. Epub 2008 Jul 16.

Migration of bisphenol A from polycarbonate baby and water bottles into water under severe conditions.

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  • 1Food Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, 251 Frederick Banting Driveway, AL: 2203D, Ottawa, Ontario K1A 0K9, Canada.


The isotope dilution headspace solid-phase microextraction and gas chromatography-mass spectrometry method for bisphenol A (BPA) developed previously was used successfully in a BPA migration study at 70 degrees C of polycarbonate baby and reusable water bottles recently sold in Canada by using the whole bottles instead of pieces cut from the bottles. Migration of BPA from the PC bottles heated at 70 degrees C was found to increase over the time in the quadratic equations. Migration levels of BPA in water varied from 228 to 521 microg L (-1) or from 0.26 to 0.90 microg cm (-2) after being heated at 70 degrees C for 6 days. The average migration rates of BPA from the PC bottles into water at 70 degrees C ranged from 1.84 to 4.83 ng cm (-2) h (-1).

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