Hum Gene Ther. 1991 Spring;2(1):5-14.

Safety issues related to retroviral-mediated gene transfer in humans.

Source

Molecular Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

Abstract

The first three approved human clinical trials utilizing retroviral-mediated gene transfer are now underway. While this technology holds great promise for the study and treatment of human disease, it also poses a number of safety concerns. In evaluating clinical protocols, potential complications and the likelihood of their occurrence are estimated by review committees so that a risk/benefit assessment can be made. Current knowledge, reviewed in this article, suggests that no acute complications secondary to retroviral-mediated gene transfer are likely, but the possibility of long-term or unforeseen sequelae in patients suggests the need for post-treatment monitoring.

PMID:: 1863639; [PubMed - indexed for MEDLINE]

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Genes and Gene Therapy - MedlinePlus Health Information

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