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J Rheumatol. 2008 Sep;35(9):1817-9. Epub 2008 Jul 15.

No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.

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  • 1Institute of Clinical Immunology and Transfusion Medicine,University of Leipzig, Leipzig, Germany.

Abstract

OBJECTIVE:

The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians. We analyzed this association in an independent, larger German cohort.

METHODS:

We genotyped 171 cases and 179 controls. Cases were subgrouped according to sex, autoantibody profiles, or clinical subsets.

RESULTS:

No association of SSc with C77G was detected in the whole dataset, in subgroups, or in combined analyses with a previous study.

CONCLUSION:

The results do not confirm PTPRC C77G as a general and independent risk factor for development of SSc.

PMID:
18634151
[PubMed - indexed for MEDLINE]
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