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    Gan To Kagaku Ryoho. 2008 Jun;35(6):1013-6.

    [A case of advanced pancreatic cancer responding to combination chemotherapy with the individual maximum repeatable dose of gemcitabine and oral S-1].

    [Article in Japanese]
    Fujimoto C, Maruyama Y, Niina Y, Fujimori N, Sumii T, Funakoshi A.

    Source

    Dept. of Gastroenterology, National Kyushu Cancer Center.

    Abstract

    The patient was a 70-year-old man with metastatic pancreatic cancer. After he received combination chemotherapy with gemcitabine and oral S-1 on day 1, he experienced severe general fatigue, anorexia and nausea. Then we changed the dose of gemcitabine from 1,000 mg/m(2) 2 to 500 mg/m(2) according to the criteria for an individual maximum repeatable dose (iMRD) determination method on day 8. His general condition recovered, and treatment schedule of gemcitabine with S-1 was continued sequentially at an outpatient clinic. His tumor marker levels, and the sizes of primary pancreatic tumor and liver metastatic lesions remarkably decreased. Partial response has been obtained for 7 months.

    PMID:
    18633236
    [PubMed - indexed for MEDLINE]

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