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Immunity. 2008 Jul 18;29(1):1-2. doi: 10.1016/j.immuni.2008.06.006.

ROS eliminate danger.

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  • The Ben May Department of Cancer Research, The University of Chicago, Chicago, IL 60637, USA. mpeter@uchicago.edu

Abstract

Necrotic cells release HMGB1 as a danger signal to activate the immune system. In this issue of Immunity, Kazama et al. (2008) identify a mechanism that determines whether HMGB1 is tolerogenic or immunogenic.

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PMID:
18631448
[PubMed - indexed for MEDLINE]
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