Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Mol Cell Biol. 2008 Sep;9(9):730-6. doi: 10.1038/nrm2453. Epub 2008 Jul 16.

Blebs lead the way: how to migrate without lamellipodia.

Author information

  • 1London Centre for Nanotechnology, London, UK. g.charras@ucl.ac.uk

Abstract

Blebs are spherical membrane protrusions that are produced by contractions of the actomyosin cortex. Blebs are often considered to be a hallmark of apoptosis; however, blebs are also frequently observed during cytokinesis and during migration in three-dimensional cultures and in vivo. For tumour cells and a number of embryonic cells, blebbing migration seems to be a common alternative to the more extensively studied lamellipodium-based motility. We argue that blebs should be promoted to a more prominent place in the world of cellular protrusions.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk