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1: J Cardiovasc Pharmacol Ther. 2008 Sep;13(3):175-82. Epub 2008 Jul 15.Click here to read Links

Effects of different levels of cigarette smoke exposure on prognostic heart rate and rate--pressure-product parameters.

Unverdorben M, van der Bijl A, Potgieter L, Venter C, Munjal S, Qiwei Liang, Meyer B, Röthig HJ.

Research, Development & Engineering, Clinical Evaluation, Philip Morris USA, Richmond, Virginia, martin.unverdorben@pmusa.com

Reduced cigarette smoke exposure in adult smokers switching from a conventional cigarette (CC) to a potential exposure-reduced electrically heated cigarette smoking system (EHCSS) and no smoking (NS) improved exercise performance. The effects of reduced smoke exposure on the prognostic parameters heart rate (HR) and rate-pressure-product (RPP) were investigated. A total of 18 male adult CC-smokers were randomized in a 3-period cross-over study to CC, EHCSS, or to NS for 3 days each before performing spiroergometry. Exposure parameters declined from CC to EHCSS and to NS. Resting HR and RPP increased from NS to EHCSS and to CC. Chronotropic response/HR recovery were more pronounced in NS than in EHCSS and CC. RPPmax was similar in NS and EHCSS and lowest during CC. Reduced tobacco smoke exposure for 3 days improved the prognostic parameters HR and RPP in an apparently dose-dependent manner.

PMID: 18628485 [PubMed - indexed for MEDLINE]