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Dermatitis. 2008 May-Jun;19(3):E10-1.

Formaldehyde, aspartame, and migraines: a possible connection.

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  • 1Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL, USA.


Aspartame is a widely used artificial sweetener that has been linked to pediatric and adolescent migraines. Upon ingestion, aspartame is broken, converted, and oxidized into formaldehyde in various tissues. We present the first case series of aspartame-associated migraines related to clinically relevant positive reactions to formaldehyde on patch testing.

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