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Curr Opin Pharmacol. 2008 Aug;8(4):427-32. doi: 10.1016/j.coph.2008.06.012. Epub 2008 Jul 22.

Src and focal adhesion kinase as therapeutic targets in cancer.

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  • 1Institute of Genetics & Molecular Medicine, Division of Cancer Biology, University of Edinburgh, Crewe Road South, Edinburgh, United Kingdom. v.brunton@ed.ac.uk

Abstract

Over the past few years small molecule inhibitors of both Src family kinases and focal adhesion kinase (FAK) have entered clinical studies for the treatment of solid tumours. These adhesion-linked kinases are involved in a number of pathways that have impact on the behaviour of tumour cells and the challenge is now, how to take these forward in the clinical setting.

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