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1: Cases J. 2008 Jul 14;1(1):33.Click here to read Click here to read Links

Primary Biliary Cirrhosis with a normal Alkaline Phosphatase: a case report.

Brostoff JM, Rashid S, McCrea D.

34 Fitzjohns Avenue, London , NW3 5NB, UK. joshbrostoff@doctors.org.uk.

ABSTRACT: A 78 year-old lady presented with abdominal swelling and fatigue. She was anaemic with mild hypoalbuminaemia, and had a normal alkaline phosphatase. Computed tomography showed hepatosplenomegaly and mild ascites. Anti mitochondrial antibodies were strongly positive, as were anti nuclear antibodies, and the gamma glutamyl-transferase was shown to be elevated. A diagnosis of primary biliary cirrhosis was made. A brief discussion of treatment of primary biliary cirrhosis follows. The case is notable for the fact that primary biliary cirrhosis can manifest clinically without an elevation in alkaline phosphatase - normally the hallmark of the disease.

PMID: 18625074 [PubMed - in process]

PMCID: PMC2475516