Triterpenoid saponins from Androsace umbellata and their anti-proliferative activities in human hepatoma cells

Planta Med. 2008 Aug;74(10):1280-4. doi: 10.1055/s-2008-1081291. Epub 2008 Jul 11.

Abstract

Two new triterpenoid saponins, along with five known ones, were isolated from the EtOH extract of the whole plants of Androsace umbellata. The structures of the new triterpenoid saponins were identified as 3- O-[ beta- D-xylopyranosyl-(1-->2)- beta- D-glucopyranosyl-(1-->4)-[ beta- D-glucopyranosyl-(1-->2)]- alpha- L-arabinopyranosyl]-3 beta-hydroxy-13 beta,28-epoxy-16-oxo-oleanan-30-al ( 1) and 3- O- beta- D-xylopyranosyl-(1-->2)- beta- D-glucopyranosyl-(1-->4)- alpha- L-arabinopyranosyl-3 beta-hydroxy-13 beta,28-epoxy-16-oxo-oleanan-30-al ( 2) on the basis of their spectral and chemical properties. All these compounds showed significant cytotoxic activities in human hepatoma cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Carcinoma, Hepatocellular / drug therapy*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Humans
  • Liver Neoplasms / drug therapy*
  • Molecular Structure
  • Primulaceae / chemistry*
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Saponins / therapeutic use
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Triterpenes / therapeutic use

Substances

  • Antineoplastic Agents, Phytogenic
  • Saponins
  • Triterpenes