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South Med J. 2008 Aug;101(8):840-1. doi: 10.1097/SMJ.0b013e31817dae27.

Fetal and neonatal Graves disease: a case report and review of the literature.

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  • 1Department of Pediatrics and Division of Newborn Medicine, Harvard Neonatal-Perinatal Fellowship Program, Children's Hospital Boston, Boston, MA, USA. muhammad.aslam@childrens.harvard.edu

Abstract

Fetal and neonatal thyrotoxicosis from maternal Graves disease is a very rare entity. Fetal symptoms result from the transplacental passage of thyroid-stimulating immunoglobulins, which persist in the neonate resulting in neonatal symptoms. We present a case of fetal and neonatal thyrotoxicosis from maternal Graves disease. Fetal symptoms were controlled with maternal administration of antithyroid drugs leading to fetal thyroid inhibition. We present this case with a brief review of the literature.

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