Psychopharmacol Bull. 1991;27(1):31-9.

Continuation and maintenance treatment of major depression with the monoamine oxidase inhibitor phenelzine: a double-blind placebo-controlled discontinuation study.

Robinson DS, Lerfald SC, Bennett B, Laux D, Devereaux E, Kayser A, Corcella J, Albright D.

Source

Bristol-Myers Squibb Company, Wallingford, CT 06492.

Abstract

Long-term treatment with antidepressant drugs has received little attention until recently. A study is reported comparing the effectiveness of maintenance treatment with phenelzine in responding major depression patients. If they responded initially to nonblind phenelzine treatment and sustained remission for 16 weeks, patients were randomized to 2-year double-blind treatment with phenelzine 60 mg/day, phenelzine 45 mg/day, or placebo. Both doses of phenelzine were significantly better than placebo in preventing relapse of depression. Phenelzine 45 mg/day may be an optimal maintenance dose for many patients.

PMID:: 1862204; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Phenelzine

Grant Support

MH-29618/MH/NIMH NIH HHS/United States

Supplemental Content

Save items

Related citations in PubMed

Phenelzine for chronic depression: a study of continuation treatment. [J Clin Psychiatry. 1986]
Phenelzine for chronic depression: a study of continuation treatment.
Harrison W, Rabkin J, Stewart JW, McGrath PJ, Tricamo E, Quitkin F. J Clin Psychiatry. 1986 Jul; 47(7):346-9.
Use of phenelzine in continuation therapy. [Neuropsychobiology. 1984]
Use of phenelzine in continuation therapy.
Davidson J, Raft D. Neuropsychobiology. 1984; 11(3):191-4.
Continuation pharmacotherapy of borderline personality disorder with haloperidol and phenelzine. [Am J Psychiatry. 1993]
Continuation pharmacotherapy of borderline personality disorder with haloperidol and phenelzine.
Cornelius JR, Soloff PH, Perel JM, Ulrich RF. Am J Psychiatry. 1993 Dec; 150(12):1843-8.
Review Continuation and maintenance treatments in major depression: the neglected role of monoamine oxidase inhibitors. [J Psychiatry Neurosci. 1997]
Review Continuation and maintenance treatments in major depression: the neglected role of monoamine oxidase inhibitors.
Kennedy SH. J Psychiatry Neurosci. 1997 Mar; 22(2):127-31.
Review Efficacy in long-term treatment of depression. [J Clin Psychiatry. 1996]
Review Efficacy in long-term treatment of depression.
Montgomery SA. J Clin Psychiatry. 1996; 57 Suppl 2:24-30.

See reviews... See all...

Cited by 3 PubMed Central articles

Blue again: perturbational effects of antidepressants suggest monoaminergic homeostasis in major depression. [Front Psychol. 2011]
Blue again: perturbational effects of antidepressants suggest monoaminergic homeostasis in major depression.
Andrews PW, Kornstein SG, Halberstadt LJ, Gardner CO, Neale MC. Front Psychol. 2011; 2:159. Epub 2011 Jul 7.
Review Continuation treatment of major depressive disorder: is there a case for duloxetine? [Drug Des Devel Ther. 2010]
Review Continuation treatment of major depressive disorder: is there a case for duloxetine?
Norman TR, Olver JS. Drug Des Devel Ther. 2010 Feb 18; 4:19-31. Epub 2010 Feb 18.
Review Continuation and maintenance treatments in major depression: the neglected role of monoamine oxidase inhibitors. [J Psychiatry Neurosci. 1997]
Review Continuation and maintenance treatments in major depression: the neglected role of monoamine oxidase inhibitors.
Kennedy SH. J Psychiatry Neurosci. 1997 Mar; 22(2):127-31.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Continuation and maintenance treatment of major depression with the monoamine ox...
Continuation and maintenance treatment of major depression with the monoamine oxidase inhibitor phenelzine: a double-blind placebo-controlled discontinuation study.
Psychopharmacol Bull. 1991 ;27(1):31-9.

PubMed
Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol e...
Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo.
J Lipid Res. 2008 Nov ;49(11):2312-22. Epub 2008 Jul 12 .

PubMed
Clinical significance of reversed vegetative subtypes of recurrent major depress...
Clinical significance of reversed vegetative subtypes of recurrent major depression.
Psychopharmacol Bull. 1991 ;27(1):17-22.

PubMed
Working group report: the roles of glycans in hemostasis, inflammation and vascu...
Working group report: the roles of glycans in hemostasis, inflammation and vascular biology.
Glycobiology. 2008 Oct ;18(10):747-9. Epub 2008 Jul 11 .

PubMed
The Omp85-related chloroplast outer envelope protein OEP80 is essential for viab...
The Omp85-related chloroplast outer envelope protein OEP80 is essential for viability in Arabidopsis.
Plant Physiol. 2008 Sep ;148(1):235-45. Epub 2008 Jul 11 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: