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Curr Opin Pharmacol. 2008 Oct;8(5):564-73. doi: 10.1016/j.coph.2008.06.008. Epub 2008 Jul 30.

How many modes of action should an antibiotic have?

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  • 1AiCuris GmbH & Co.KG, Friedrich-Ebert Strasse 475, Building 302, D-42117 Wuppertal, Germany. heike.broetz-oesterhelt@aicuris.com

Abstract

All antibiotics that have been successfully employed for decades as monotherapeutics in the treatment of bacterial infections rely on mechanisms of bacterial growth inhibition which are by far more complex than inhibition of a single enzyme. Such successful antibiotics have in common that they address several targets in parallel and/or that their targets are encoded by multiple genes. Such multiplicity of targets and of target genes has the advantage that the emergence of spontaneous target-related resistance is a comparatively slow process. Recently registered antibiotics and novel antibiotics in development are discussed in the light of this promising concept of antibacterial polypharmacology.

PMID:
18621146
[PubMed - indexed for MEDLINE]
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