Cell Host Microbe. 2008 Jul 17;4(1):3-5.

HIV and chemokine binding to red blood cells--DARC matters.

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MRC Laboratories Atlantic Road, PO Box 273 Banjul, The Gambia, West Africa.

Abstract

A mutation in the Duffy antigen (DARC) that abrogates receptor expression and gives profound protection against some malaria species has become almost universal in African populations. He et al. (2008) show that this polymorphism also leads to significantly increased susceptibility to HIV-1 infection but, paradoxically, to prolonged survival in HIV-1-infected subjects.

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Cell Host Microbe. 2008 Jul 17;4(1):52-62.

PMID:: 18621004; [PubMed - indexed for MEDLINE]

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Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility. [Cell Host Microbe. 2008]
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He W, Neil S, Kulkarni H, Wright E, Agan BK, Marconi VC, Dolan MJ, Weiss RA, Ahuja SK. Cell Host Microbe. 2008 Jul 17; 4(1):52-62.
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