Format

Send to

Choose Destination
See comment in PubMed Commons below
J Pharm Biomed Anal. 2008 Nov 4;48(3):592-7. doi: 10.1016/j.jpba.2008.05.029. Epub 2008 Jul 10.

Robust Raman measurement of hydrogen peroxide directly through plastic containers under the change of bottle position and its long-term prediction reproducibility.

Author information

  • 1Department of Chemistry, Hanyang University, Seoul 133-791, Republic of Korea.

Abstract

Hydrogen peroxide concentration in antiseptic solutions has been non-destructively measured with the use of wide area illumination (WAI) scheme by applying a laser beam directly through a plastic container. The prediction accuracy was comparable to that from the use of quartz cell instead of a plastic bottle as well as near-infrared (NIR) prediction result in the previous study. Although the position of a plastic bottle was artificially changed in three-dimensional directions up to +/-10 mm to simulate real situation of practical measurement, the prediction accuracy was not degraded within +/-5 mm positional variation. This robust prediction performance was powered by the merits of WAI scheme that could provide improved reproducibility by illuminating large sample areas as well as less sensitivity of sample placement by the design of long focal length. Moreover, the prediction accuracy was successfully maintained over a long period of time. Finally, the prediction was also reproducible under the situation of laser power variation. The overall results demonstrate that WAI Raman scheme can provide robust and non-destructive quantitative analysis for not only hydrogen peroxide in antiseptic solution, but also other active pharmaceutical ingredients in diverse containers.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk