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    AIDS. 2008 Jul 31;22(12):1515-7.

    Single-nucleotide polymorphisms in human beta-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters.

    Baroncelli S, Ricci E, Andreotti M, Guidotti G, Germano P, Marazzi MC, Vella S, Palombi L, De Rossi A, Giuliano M.

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    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy. silvia.baroncelli@iss.it

    Abstract

    We analyzed single nucleotide polymorphisms in the 5'-untranslated region (-44C/G and -52G/A) of the beta-defensin-1 gene in 78 Mozambican HIV-1-infected mothers. We observed significantly lower levels of HIV-1 RNA in breast milk, but not in plasma, in women with the -52GG genotype versus women with the -52GA and -52AA genotypes, supporting the hypothesis that different expression of beta-defensins could have an impact on viral replication in breast milk.

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    PMID:
    18614876
    [PubMed - indexed for MEDLINE]

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