Familial myeloma. [N Engl J Med. 2008]

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1: N Engl J Med. 2008 Jul 10;359(2):152-7. Links

Familial myeloma.

Lynch HT, Ferrara K, Barlogie B, Coleman EA, Lynch JF, Weisenburger D, Sanger W, Watson P, Nipper H, Witt V, Thomé S.

Creighton University School of Medicine, Omaha, USA.

We describe a family with five cases of multiple myeloma, three cases of monoclonal gammopathy of undetermined significance (MGUS), and five cases of prostate cancer in two generations. The putative progenitor had progeny with two female partners. The progeny had prostate cancer, multiple myeloma, and MGUS. 2008 Massachusetts Medical Society

PMID: 18614782 [PubMed - indexed for MEDLINE]

The predictive power of serum kappa/lambda ratios for discrimination between monoclonal gammopathy of undetermined significance and multiple myeloma. [Clin Chem Lab Med. 2005]
Assessment of the analytical performance and the sensitivity of serum free light chains immunoassay in patients with monoclonal gammopathy. [Clin Biochem. 2007]
Role of different hematologic variables in defining the risk of malignant transformation in monoclonal gammopathy. [Blood. 1996]
Familial multiple myeloma: a family study and review of the literature. [J Natl Cancer Inst. 2001]
Monoclonal gammopathy of undetermined significance (MGUS) in patients with solid tumors: effects of chemotherapy on the monoclonal protein. [Ann Hematol. 2004]
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Familial myeloma.

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